Abstract
Antarctic benthic communities are regulated by abundant interactions of different
types among organisms, such as predation, competition, etc. Predators are usually
sea stars, with omnivorous habits, as well as other invertebrates. Against this strong
predation pressure, many organisms have developed all sorts of defensive strategies,
including chemical defenses. Natural products are thus quite common in Antarctic organisms
with an important ecological and pharmacological potential. In this paper, the chemical
defenses of the Antarctic organisms studied during the ECOQUIM and ACTIQUIM projects,
as well as their pharmacological potential, are reviewed. For the ecological defenses,
predation against the sea star Odontaster validus is analyzed and evaluated along depth gradients as well as considering the lifestyle
of the organisms. For the pharmacological activity, the anticancer, anti-inflammatory,
and antibacterial activities tested are evaluated here. Very often, only crude extracts
or fractions have been tested so far, and therefore, the natural products responsible
for such activities remain yet to be identified. Even if the sampling efforts are
not uniform along depth, most ecologically active organisms are found between 200
and 500 m depth. Also, from the samples studied, about four times more sessile organisms
possess chemical defenses against the sea star than the vagile ones; these represent
50 % of sessile organisms and 35 % of the vagile ones, out of the total tested, being
active. Pharmacological activity has not been tested uniformly in all groups, but
the results show that relevant activity is found in different phyla, especially in
Porifera, Cnidaria, Bryozoa, and Tunicata, but also in others. No relationship between
depth and pharmacological activity can be established with the samples tested so far.
More studies are needed in order to better understand the ecological relationships
among Antarctic invertebrates mediated by natural products and to fully explore their
pharmacological potential.
Key words
chemical ecology - marine benthos - antarctic invertebrates - chemical defense - cytotoxicity
- anti-inflammatory activity - antibacterial activity
